The Innate Immunity research group conducts interdisciplinary research in the role of innate immune cells in human health and disease.
Our investigators are co-located on level E of the South Academic Block at University Hospital Southampton. The group has numerous collaborative projects, and diverse expertise including lymphocyte subsets such as Natural Killer and CD1-responsive T cells, macrophage and fibroblast biology, proteases and bioinformatic/multiomic approaches. Experimental approaches include analysis of patient-derived tissue, advanced cellular modelling, in vivo models and translational studies spanning a range of diseases, including infection, inflammation, wound healing, cancer, metabolic and lung disease.
Integrating bioinformatic analysis of clinical samples and advanced cell culture to understand tuberculosis immunopathology and find new host-directed therapeutic targets to treat tuberculosis.
Dr Blunt leads a research team focused on natural killer (NK) cells, novel cancer immunotherapies and haematological malignancies.
Dr Vallejo specialises in the development of cutting-edge technologies for single cell and spatial transcriptomics with a focus on infectious diseases.